Fast detection of maximal exact matches via fixed sampling of query K-mers and Bloom filtering of index K-mers.
Identifieur interne : 000570 ( Main/Exploration ); précédent : 000569; suivant : 000571Fast detection of maximal exact matches via fixed sampling of query K-mers and Bloom filtering of index K-mers.
Auteurs : Yuansheng Liu [Australie] ; Leo Yu Zhang [Australie] ; Jinyan Li [Australie]Source :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2019.
Abstract
Detection of maximal exact matches (MEMs) between two long sequences is a fundamental problem in pairwise reference-query genome comparisons. To efficiently compare larger and larger genomes, reducing the number of indexed k-mers as well as the number of query k-mers has been adopted as a mainstream approach which saves the computational resources by avoiding a significant number of unnecessary matches.
DOI: 10.1093/bioinformatics/btz273
PubMed: 30994891
Affiliations:
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<front><div type="abstract" xml:lang="en">Detection of maximal exact matches (MEMs) between two long sequences is a fundamental problem in pairwise reference-query genome comparisons. To efficiently compare larger and larger genomes, reducing the number of indexed k-mers as well as the number of query k-mers has been adopted as a mainstream approach which saves the computational resources by avoiding a significant number of unnecessary matches.</div>
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